With the recent availability of myelin oligodendrocyte glycoprotein antibody (MOG-Ab) testing in China, and the acceptance of MOG-Abs-associated disorders as a unique demyelinating disease of the central nervous system (CNS) 7, the concept of ON as “atypical” depending on the antibody status, as well as the treatment strategy, has been updated 8.įor a long time, the epidemiological and clinical characteristics of ON in Asian patients were not as clear as those of MS in Caucasians. However, some patients would present with recurrent disease despite testing negative for AQP4-Abs, confusing the physicians. Accordingly, patients were divided into two categories: those with multiple sclerosis-related ON (MS-ON), and those with atypical ON, such as that observed in NMO-spectrum disorders (NMOSD) 1, 2, 3, 4, 5, 6. Up until a decade ago, patients with optic neuritis (ON) in China were primarily tested for aquaporin-4 antibodies (AQP4-Abs) due to its high specificity and sensitivity in diagnosing neuromyelitis optica (NMO). Despite RNFL and GCIPL thinning, the MOG-ON group’s outcome was as favorable as that of the seronegative-ON group, whereas the AQP4-ON group showed unsatisfactory results. Macular ganglion cell-inner plexiform layer (GCIPL) revealed the same pattern. Relapse rates were higher in the MOG-ON and AQP4-ON groups than in the seronegative-ON group ( p < 0.001). The proportion of eyes with best-corrected visual acuity > 20/25 at the 3-year follow-up was similar between the MOG-ON and seronegative-ON groups the proportion in both groups was higher than that in the AQP4-ON group ( p < 0.001). They were divided into the myelin oligodendrocyte glycoprotein-seropositive (MOG-ON), aquaporin-4-seropositive (AQP4-ON), and double-seronegative (seronegative-ON) groups, and their clinical characteristics and imaging findings were evaluated and compared.
This prospective study recruited patients with new-onset ON between January 2015 and March 2017 who were followed-up for 3 years. To evaluate the clinical characteristics of optic neuritis (ON) with different phenotypes.
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